SYNTHETIC STUDIES OF MICROCOLIN-B

The octanoyl and desacetyl analogue of the lipopeptide microcolin B is olated from Lyngbya majuscula was synthesized using a segment condensa tion strategy. To achieve this the unique 1-prolyl-methyl-2-pyrroline unit was prepared from Boc-Pro-Ala-OH in a five step synthesis. This s egment was coupled to the dipeptide Boc-Thr-MeVal-OH using PyBoP(R). D eprotection followed by PyBroP(R)-mediated coupling with octanoyl-MeLe u-OH finally led to the octanoyl analogue of desacetylmicrocolin B.