TOTAL SYNTHESIS OF NONACTIN

Authors
LEE JY KIM BH
Citation
Jy. Lee et Bh. Kim, TOTAL SYNTHESIS OF NONACTIN, Tetrahedron, 52(2), 1996, pp. 571-588
Citations number
66
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
52
Issue
2
Year of publication
1996
Pages
571 - 588
Database
ISI
SICI code
0040-4020(1996)52:2<571:TSON>2.0.ZU;2-W
Abstract
Utilizing the efficient preparation of (+)-nonactic acid(2a) and (-)-m ethyl 8-epi-nonactate (4b) starting from optically active 2-isoxazolin es 5a and 5b, respectively, the total synthesis of nonactin has been a ccomplished. Based on the high dilution Version of the Yamaguchi's met hod, the final macrolactonization has been completed in high yield.