AMINO-ACIDS AND PEPTIDES .25. PREPARATION OF FIBRONECTIN-RELATED PEPTIDE POLY(ETHYLENE GLYCOL) HYBRIDS AND THEIR INHIBITORY EFFECT ON EXPERIMENTAL METASTASIS

Authors
KAWASAKI K NAMIKAWA M YAMASHIRO Y IWAI Y HAMA T TSUTSUMI Y YAMAMOTO S NAKAGAWA S MAYUMI T
Citation
K. Kawasaki et al., AMINO-ACIDS AND PEPTIDES .25. PREPARATION OF FIBRONECTIN-RELATED PEPTIDE POLY(ETHYLENE GLYCOL) HYBRIDS AND THEIR INHIBITORY EFFECT ON EXPERIMENTAL METASTASIS, Chemical and Pharmaceutical Bulletin, 43(12), 1995, pp. 2133-2138
Citations number
23
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
43
Issue
12
Year of publication
1995
Pages
2133 - 2138
Database
ISI
SICI code
0009-2363(1995)43:12<2133:AAP.PO>2.0.ZU;2-D
Abstract
Hybrids of fibronectin-related peptides [Arg-Gly-Asp (RGD) Arg-Gly-Asp -Ser (RGDS)] and poly(ethylene glycol) (PEG) were prepared and their i nhibitory effects on experimental metastasis in mice were examined. Th e inhibitory effect of RGD was markedly potentiated by hybrid formatio n with poly(ethylene glycol) #6000. As to inhibitory effect, RGD was m ore potent than RGDS and RGD PEG hybrids were superior to RGDS PEG hyb rids. Hybrid formation with PEG #6000 was more effective than that wit h PEG #4000.