PHARMACOLOGICALLY ACTIVE COMPONENTS OF TODOPON PUOK (FAGRAEA-RACEMOSA), A MEDICINAL PLANT FROM BORNEO

The lignans of (+)-pinoresinol, (+)-epipinoresinol, (+)-lariciresinol and (+)-isolariciresinol together with phenols such as syringaldehyde and 7,8-dihydro-7-oxy-coniferyl alcohol were isolated from Todopon Puo k (Fagraea racemosa JACK ex WALL.), a medicinal plant from Borneo, usi ng a bioassay of the relaxation effect on norepinephrine (NE)-induced contraction in rat aortic strips. The plant extract also exhibited ana lgesic properties in the acetic acid-induced writhing and tail pressur e tests in mice, with the activity being concentrated in the lignan fr action. (+)-Pinoresinol showed analgesic effect on writhing symptoms i n mice which were dose-dependent, and produced local anesthesia in gui nea pigs.