T. Makino et al., BEHAVIOR OF PREGELATINIZED STARCH DURING GRANULATION AND ITS INFLUENCE ON TABLET PROPERTIES, Chemical and Pharmaceutical Bulletin, 43(12), 1995, pp. 2264-2266
Using pregelatinized starch as a binder, fluidized-bed granulation and
agitation granulation were attempted to investigate the behavior of s
tarch and to examine its relationship with the resultant tablet proper
ties (hardness and disintegration). The amounts of soluble starch befo
re and after granulation were measured, Also, hardness and the disinte
gration time of the resultant tablets were measured, In fluidized-bed
granulation, the soluble starch content did not change noticeably duri
ng granulation, thus exerting no influence on tablet properties, On th
e other hand, in agitation granulation, the soluble starch content inc
reased, so that the disintegration time of the resultant tablets was p
rolonged, This may be because the soluble starch increased during agit
ation granulation due to a large shearing force and inhibited water pe
netration into the tablet and/or because some changes occurred in the
swelling properties of the pregelatinized starch. Therefore, when preg
elatinized starch is used as a binder, the fluidized-bed method is rec
ommended to consistently obtain satisfactory tablet properties.