COMPUTER-SIMULATION OF THE PHENOMENON OF SUPERACTIVITY OF NEUROPHARMACOLOGICAL EMBRYOTOXIC DRUGS ON THE BASIS OF TOPOLOGICAL PARAMETERS OF THE MOLECULES AND METHODS OF THEORY OF IMAGE RECOGNITION

Discriminant functions were obtained on the basis of experimental data on the superactivity of synthetic analogues of the natural biogenic a mines (26 active and 33 superactive derivatives of benzene and indole) , which allow prognostication of the superactivity of embryotoxic comp ounds with respect to sea urchin embryos on the basis of calculated pa rameters of the molecules. During reclassification of molecules of the learning sample, the percentage of correct recognition is 73.1 for ac tive, 87.9 for superactive, and 81.4% for the entire data bank. The pr ognostication capacity of the obtained functions is 73 - 80%.