BASIC HYDROLYSIS OF 2-[F-18]FLUORO-1,3,4,6-TETRA-O-ACETYL-D-GLUCOSE IN THE PREPARATION OF 2-[F-18]FLUORO-2-DEOXY-D-GLUCOSE

Authors
FUCHTNER F STEINBACH J MADING P JOHANNSEN B
Citation
F. Fuchtner et al., BASIC HYDROLYSIS OF 2-[F-18]FLUORO-1,3,4,6-TETRA-O-ACETYL-D-GLUCOSE IN THE PREPARATION OF 2-[F-18]FLUORO-2-DEOXY-D-GLUCOSE, Applied radiation and isotopes, 47(1), 1996, pp. 61-66
Citations number
13
Categorie Soggetti
Nuclear Sciences & Tecnology","Radiology,Nuclear Medicine & Medical Imaging
Journal title
Applied radiation and isotopes
ISSN journal
09698043 → ACNP
Volume
47
Issue
1
Year of publication
1996
Pages
61 - 66
Database
ISI
SICI code
0969-8043(1996)47:1<61:BHO2I>2.0.ZU;2-Z
Abstract
In contrast to the commonly used acid hydrolysis of 2-[F-18]fluoro-1,3 ,4,6-tetra-O-acetyl-D-glucose to [F-18]FDG, basic hydrolysis is a shor t, high-yield procedure at room temperature. In case of nucleophilic [ F-18]FDG synthesis the yield of removing the protective groups is quan titative. Using the electrophilic procedure the yield is about 20% hig her than in acid hydrolysis. Under optimal conditions (0.3 M NaOH) the reaction is already completed within 1 min. In alkaline solutions the formed [F-18]FDG is stable for more than 20 min. Additionally, the fo rmation of 2-deoxy-2-chloro-D-glucose is avoided.