BENZOTRIAZOLE AS A SYNTHETIC AUXILIARY - BENZOTRIAZOLYLALKYLATIONS AND BENZOTRIAZOLE-MEDIATED HETEROALKYLATION

Recent advances in the use of benzotriazole as a synthetic auxiliary f or the preparation of numerous organic derivatives are reviewed. Benzo triazolyl derivatives are converted into other benzotriazolyl intermed iates for further transformations. The displacement of the benzotriazo le moiety by nucleophiles affords many useful organic compounds. Thus, (alpha-heteroalkyl)benzotriazoles are proved to be efficient aminoalk ylation, amidoalkylation, alkoxyalkylation, acyloxyalkylation, and thi oalkylation agents for many classes of compounds.