SEPARATION OF TETRACYCLINE AND ITS RELATED SUBSTANCES BY CAPILLARY ZONE ELECTROPHORESIS

Authors
VANSCHEPDAEL A SAEVELS J LEPOUDRE X KIBAYA R GANG NZ ROETS E HOOGMARTENS J
Citation
A. Vanschepdael et al., SEPARATION OF TETRACYCLINE AND ITS RELATED SUBSTANCES BY CAPILLARY ZONE ELECTROPHORESIS, HRC. Journal of high resolution chromatography, 18(11), 1995, pp. 695-698
Citations number
12
Categorie Soggetti
Chemistry Analytical
Journal title
HRC. Journal of high resolution chromatography → ACNP
ISSN journal
09356304
Volume
18
Issue
11
Year of publication
1995
Pages
695 - 698
Database
ISI
SICI code
0935-6304(1995)18:11<695:SOTAIR>2.0.ZU;2-G
Abstract
Tetracycline was separated from its main impurities 4-epitetracycline, anhydrotetracycline, 4-epianhydrotetracycline, chlortetracycline, and demethyltetracycline by capillary electrophoresis. Systematic method development was performed in which following parameters were consecuti vely optimized: type and pH of the buffer, buffer concentration, type and concentration of organic modifier, voltage and temperature, Qualit ative and quantitative aspects of the method are compared with liquid chromatography.