Background: The purpose of this study was to compare ambulatory laparo
scopic cholecystectomy (LC) with overnight LC and to determine its saf
ety and the factors which will predict its success. Methods: Ambulator
y LC was defined as LC followed by less than a 12-h stay in the ambula
tory surgery unit; overnight LC was defined as LC followed by a hospit
al admission of less than 24 h. A retrospective chart review was compl
eted. Results: One hundred forty-nine ambulatory LC, were performed in
an 18-month period. Ninety-one were successful (61%); 58 patients req
uired overnight admission for pain management, control of nausea, or t
heir reluctance to be discharged. There were five complications and no
mortalities. The duration of the surgical procedure was the only sign
ificant objective factor we could find in predicting success of ambula
tory LC. Conclusions: We conclude that ambulatory LC is safe and effec
tive in treating patients requiring cholecystectomy. The duration of t
he procedure and the patient's own motivation are key factors in predi
cting success of early discharge.