INHIBITION OF EXTRACELLULAR-MATRIX AND SERUM-PROTEIN BINDING TO STAPHYLOCOCCUS-AUREUS BY HEPARIN AND VARIOUS POLYSULFATED AGENTS

Authors
PASCU C HIRMO S LJUNGH A WADSTROM T
Citation
C. Pascu et al., INHIBITION OF EXTRACELLULAR-MATRIX AND SERUM-PROTEIN BINDING TO STAPHYLOCOCCUS-AUREUS BY HEPARIN AND VARIOUS POLYSULFATED AGENTS, Medical microbiology letters, 4(8), 1995, pp. 397-405
Citations number
12
Categorie Soggetti
Microbiology
Journal title
Medical microbiology letters → ACNP
ISSN journal
10184627
Volume
4
Issue
8
Year of publication
1995
Pages
397 - 405
Database
ISI
SICI code
1018-4627(1995)4:8<397:IOEASB>2.0.ZU;2-G
Abstract
Cells of Staphylococcus aureus strain Cowan 1 express high binding of lactoferrin, vitronectin, thrombospondin and fibronectin. Binding of t hese extracellular matrix and serum proteins was inhibited by heparin and heparin-like molecules (pentosan polysulphate, fucoidan), sulphate d polyanions (suramin) and by sulphated dyes (Evans blue, Trypan blue and Congo red) but not by nonsulphated and carboxylated compounds.