Football is a contact sport which involves heading the ball and clash
of heads, both having the potential for causing repetitive minor head
injury. Much of the research on the association between football and A
lzheimer's disease (AD) is flawed, but what is available suggests that
footballers are more likely to have EEG abnormalities, cortical atrop
hy and mild neurological abnormalities than controls. It is also known
that head injury may precipitate a cascade of events leading to AD pa
thology by increasing the expression of amyloid precursor protein and
increasing amyloid deposition. It is not known if footballers have an
increased risk of dementia, but it is possible that they do. Preventat
ive action could be taken by football's governing bodies to reduce the
risk of brain damage as a result of head injury and subsequent develo
pment of dementia.