POTENTIATING EFFECTS ON PILOCARPINE-INDUCED SALIVA SECRETION, BY EXTRACTS AND N-CONTAINING SUGARS DERIVED FROM MULBERRY LEAVES, IN STREPTOZOCIN-DIABETIC MICE

The effects of hot water extracts and six compounds of N-containing su gars, 1-deoxynojirimycin (DNJ), N-methyl-DNJ (N-Me-DNJ), 2-O-alpha-D-g alactopyranosl-DNJ (GAL-DNJ), fagomine, 1,4-dideoxy-1,4-imino-D-aralbi nitol (DAB), and 1,2 alpha 3 beta,4 alpha-tetrahydroxynortropane (caly stegin B-2), derived from mulberry leaves (Morus alba L.), were invest igated on pilocarpine-induced saliva secretion in streptozocin (STZ)-i nduced diabetic mice. The extracts (100 and 200 mg/kg, i.p.) significa ntly potentiated the pilocarpine-induced salivary how but not the prot ein content. The component compounds (37.5-300 mu mol/kg) potentiated the saliva secretion, and the potency order was DAB>fagomine>GAL-DNJ. Only fagomine significantly increased the protein content in the saliv a. The potentiation of pilocarpine-induced salivary flow was correlate d with anti-hyperglycemic effects by the extract and GAL-DNJ from mulb erry leaves in the same dose ranges.