3-DEOXYGLUCOSONE REDUCTASE IN DOG ADRENAL-GLANDS - IDENTIFICATION AS ALDOSE REDUCTASE

Authors
MATSUURA K SATO K DEYASHIKI Y NAKANISHI M HARA A
Citation
K. Matsuura et al., 3-DEOXYGLUCOSONE REDUCTASE IN DOG ADRENAL-GLANDS - IDENTIFICATION AS ALDOSE REDUCTASE, Biological & pharmaceutical bulletin, 18(12), 1995, pp. 1765-1767
Citations number
25
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Biological & pharmaceutical bulletin → ACNP
ISSN journal
09186158
Volume
18
Issue
12
Year of publication
1995
Pages
1765 - 1767
Database
ISI
SICI code
0918-6158(1995)18:12<1765:3RIDA->2.0.ZU;2-E
Abstract
3-Deoxyglucosone is one of the major cytotoxic intermediates in the Ma illard reaction. Adrenal glands showed the highest NADPH-linked 3-deox yglucosone reductase activity of dog tissues. The enzyme was purified to homogeneity from the adrenal glands, and demonstrated to be structu rally, functionally and immunologically identical with aldose reductas e, which comprises about 6% of the soluble adrenal proteins.