INDUCTION OF HSP-70 AFTER HYPEROSMOTIC OPENING OF THE BLOOD-BRAIN-BARRIER IN THE RAT

Authors
RICHMON JD FUKUDA K SHARP FR NOBLE LJ
Citation
Jd. Richmon et al., INDUCTION OF HSP-70 AFTER HYPEROSMOTIC OPENING OF THE BLOOD-BRAIN-BARRIER IN THE RAT, Neuroscience letters, 202(1-2), 1995, pp. 1-4
Citations number
33
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
202
Issue
1-2
Year of publication
1995
Pages
1 - 4
Database
ISI
SICI code
0304-3940(1995)202:1-2<1:IOHAHO>2.0.ZU;2-A
Abstract
The cellular response resulting from breakdown of the blood-brain barr ier was evaluated 24 h after hyperosmotic infusion of mannitol into th e internal carotid artery in the rat. Heat shock protein (HSP-70), a m arker of cellular stress and/or injury, was induced in scattered patch es of neurons and glia in regions of barrier breakdown. These findings suggest that osmotically induced breakdown of the blood-brain barrier may result in cell injury.