ANTIMICROBIAL MANAGEMENT OF CHRONIC SINUSITIS IN CHILDREN

Authors
Citation
I. Brook et P. Yocum, ANTIMICROBIAL MANAGEMENT OF CHRONIC SINUSITIS IN CHILDREN, Journal of Laryngology and Otology, 109(12), 1995, pp. 1159-1162
Citations number
16
Categorie Soggetti
Otorhinolaryngology
ISSN journal
00222151
Volume
109
Issue
12
Year of publication
1995
Pages
1159 - 1162
Database
ISI
SICI code
0022-2151(1995)109:12<1159:AMOCSI>2.0.ZU;2-X
Abstract
This study retrospectively investigated the microbiology and managemen t of 40 children who suffered from chronic sinusitis. The sinuses infe cted were the maxillary (15 cases), ethmoid (13), and frontal (seven). Pansinusitis was present in five patients. All aspirates were culture d for aerobic and anaerobic bacteria. A total of 121 isolates (97 anae robic and 24 aerobic) were recovered. Anaerobes were recovered from al l 37 culture-positive specimens, and in 14 cases (38 per cent) they we re mixed with aerobes. Twenty-three beta-lactamase-producing bacteria were isolated from 16 (43 per cent) patients. The 15 patients who rece ived clindamycin had the most rapid response to therapy and a change o f therapy and surgical drainage was required in one case. Of the 16 pa tients who received amoxycillin or ampicillin, 16 responded to therapy , six needed a change of therapy, including four who also had surgical drainage. Of the six who were treated with erythromycin, three needed antibiotic change, two with surgical drainage. Of the three that rece ived cefaclor, two were cured, and one had an antibiotic change. Resis tant organisms were recovered in all the cases that required therapeut ic change. These findings support the important role of anaerobic bact eria in the polymicrobial cause of chronic sinusitis in children, and the superiority of therapy effective against these organisms.