A COMPARISON OF TRIMEDOXIME, OBIDOXIME, PRALIDOXIME AND HI-6 IN THE TREATMENT OF ORAL ORGANOPHOSPHORUS INSECTICIDE POISONING IN THE RAT

This study summarizes the results of examination of acute oral toxicit y of 26 organophosphorus insecticides in rats. The effectiveness of tr imedoxime, obidoxime, pralidoxime and HI-6, given with atropine and di azepam, was tested in the treatment of poisoning with 2 LD(50) Of the insecticides. It was shown that the oximes were potent antidotes in po isoning with phosphate insecticides. Obidoxime, pralidoxime and HI-6 h ad low effectiveness in the treatment of poisoning with phosphonates a nd phosphorothiolates. However, none of the oximes was an effective an tidote in poisoning with dimethoate and pyridafenthion. Trimedoxime wa s the most effective oxime in the treatment of insecticide poisoning, being successful especially at the lowest tested doses.