ON THE FUNCTIONAL-SIGNIFICANCE OF PRIMATE RETINAL DOPAMINE-RECEPTORS

Diverse dopamine receptors have been identified in the primate retina. Evidence summarized from human and monkey retinal electrophysiologica l studies (ERG) suggests that separate D1 and D2 receptor activation r esults in stimulus dependent antagonistic effects. Studies were perfor med using Haloperidol, l-sulpiride, CY 208-243 and dopamine. It is inf erred that the antagonistic functions of D1 and D2 receptors synergist ically determine the inverted U-shaped spatial contrast response funct ion of the primate retina. An understanding of the logic performed by retinal D1 and D2 receptors may be useful to discern properties of the role of diverse dopamine receptors in basal ganglia DA circuits.