EFFECTS OF SHORT-TERM TREATMENT WITH THE THROMBOXANE SYNTHESIS BLOCKER INDOBUFEN ON PRESSOR AND DEPRESSOR HUMORAL-FACTORS IN HEALTHY HUMANS

Authors
ZACHARIEVA S ORBETZOVA M TCHARAKTCHIEV D ANGELOVAGATEVA P ANDONOVA K
Citation
S. Zacharieva et al., EFFECTS OF SHORT-TERM TREATMENT WITH THE THROMBOXANE SYNTHESIS BLOCKER INDOBUFEN ON PRESSOR AND DEPRESSOR HUMORAL-FACTORS IN HEALTHY HUMANS, Methods and findings in experimental and clinical pharmacology, 17(9), 1995, pp. 615-619
Citations number
35
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Methods and findings in experimental and clinical pharmacology → ACNP
ISSN journal
03790355
Volume
17
Issue
9
Year of publication
1995
Pages
615 - 619
Database
ISI
SICI code
0379-0355(1995)17:9<615:EOSTWT>2.0.ZU;2-1
Abstract
Twelve healthy subjects were studied after single dose (200 mg p.o.) a nd 3 days (2 x 200 mg daily p.o.) indobufen treatment. Our findings in dicated that in addition to well-known antiaggregant activity indobufe n significantly decreases thromboxane B-2 and increases 6-keto-prostag landin F-1 after acute and short-term treatment. The activity of renin -angiotensin-aldosterone system and kalli-krein-kinin system did not c hange significantly after both experimental periods. It seems also unl ikely that atrial natriuretic peptide mediates the effects of the drug .