DILTIAZEM FOR PREVENTION OF ACOUSTICAL TRAUMA DURING OTOLOGIC SURGERY

Citation
J. Maurer et al., DILTIAZEM FOR PREVENTION OF ACOUSTICAL TRAUMA DURING OTOLOGIC SURGERY, ORL, 57(6), 1995, pp. 319-324
Citations number
28
Categorie Soggetti
Otorhinolaryngology
Journal title
ORLACNP
ISSN journal
03011569
Volume
57
Issue
6
Year of publication
1995
Pages
319 - 324
Database
ISI
SICI code
0301-1569(1995)57:6<319:DFPOAT>2.0.ZU;2-4
Abstract
100 patients were tested in a prospective, randomized, double-blinded study to assess the perioperative efficacy of a calcium channel blocke r (diltiazem) in preventing acoustical trauma during otologic surgery. The patients were randomly divided into a therapy group (diltiazem) a nd a control group (placebo). Bone conduction hearing thresholds were examined preoperatively and again 1 day and 3 months postoperatively. Frequency-dependent changes in postoperative bone conduction and the n umber of patients with various degrees of postoperative hearing loss i n both groups were statistically analyzed. The results indicated only a small postoperative hearing loss after ear surgery in both groups. T here was a tendency for better results in the therapy group, but this was not statistically significant. Despite favorable results in animal trials utilizing different types of noise and the prophylactic applic ation of diltiazem, further studies in humans are needed to determine the role of calcium antagonist drugs in the prophylaxis or treatment o f acoustical trauma.