INSULIN-LIKE GROWTH FACTOR-I AND FACTOR-2 AND THEIR ROLE IN THE REEPITHILIALIZATION OF WOUNDS - INTERACTIONS WITH INSULIN-LIKE GROWTH-FACTOR BINDING-PROTEIN TYPE-1

Insulin like growth factor (IGF) 1 and 2 which are present and activel y synthesised in the wound fluid stimulate several cell types involved in the process of wound healing. To investigate the role of IGF-1 and 2 and in addition, the association between IGF and their carrier prot eins, IGF binding proteins (IGFBP), we have used a newly established m odel for human wound healing in fresh biopsy material. Histological ex amination shows that IGF-1 stimulates efficient reepithelialisation of the wounds both alone and in the presence of recombinant IGFBP-1. In contrast, IGF-2 stimulates healing only when used in combination with IGFBP-I. These findings suggest that the two IGFs and their carrier pr oteins may function during different phases of wound healing and that both IGF-1 and 2 act as potent inducers of wound healing; this may hav e direct clinical implications.