Tn. Glenn et al., FINITE-ELEMENT ANALYSIS OF TEMPERATURE-CONTROLLED COAGULATION IN LASER-IRRADIATED TISSUE, IEEE transactions on biomedical engineering, 43(1), 1996, pp. 79-87
The Theoretical study of thermal damage processes in laser irradiated
tissue provides further insight into the design of optimal coagulation
procedures. Controlled laser coagulation of tissue was studied theore
tically using a finite element method with a modulating laser heat sou
rce to simulate feedback controlled laser delivery with a constant sur
face temperature. The effects of uncertainty in scattering and absorpt
ion properties of the tissue, thermal denaturation induced changes in
optical properties, and surface convection were analyzed. Compared to
a single pulse CW irradiation in which a doctor would presumably stop
CW laser delivery after noticing some effect such as vaporization or c
arbonization, the constant surface temperature scenario provided a bet
ter overall control over the coagulation process. In particular, predi
ction of coagulative damage in a constant temperature scenario was les
s sensitive to uncertainties in optical properties and their dynamic c
hanges during the course of coagulation. Also, subsurface overheating
under surface convective conditions could be compensated for under con
stant temperature irradiation by lowering the surface temperature.