A CASE OF IDIOPATHIC MYELOFIBROSIS WITH ALLOIMMUNIZATION TO HLA-IDENTICAL PLATELET TRANSFUSIONS NOT RESPONSIVE TO ANTIBODY ABSORPTION OVER PROTEIN-A COLUMNS

Authors
MENICUCCI A DIPIETRO G VENTURINI S AVANZI G
Citation
A. Menicucci et al., A CASE OF IDIOPATHIC MYELOFIBROSIS WITH ALLOIMMUNIZATION TO HLA-IDENTICAL PLATELET TRANSFUSIONS NOT RESPONSIVE TO ANTIBODY ABSORPTION OVER PROTEIN-A COLUMNS, Transfusion science, 16(4), 1995, pp. 391-395
Citations number
5
Categorie Soggetti
Hematology
Journal title
Transfusion science → ACNP
ISSN journal
09553886
Volume
16
Issue
4
Year of publication
1995
Pages
391 - 395
Database
ISI
SICI code
0955-3886(1995)16:4<391:ACOIMW>2.0.ZU;2-3
Abstract
A case of idiopathic myelofibrosis has been treated with HLA-identical platelet apheresis concentrates. After a short period the patient als o developed refractoriness to the haploidentical siblings. Protein A c olumns were used to absorb the platelet antibodies with no result. Now two apheresis platelet concentrates are used every month, crossmatche d negative products produce good results maintaining cell counts betwe en 20 and 30 X 10(9)/L. The immune mechanism involved is difficult to understand.