BACKGROUND: This study was done to identify obstacles in the early dia
gnosis and treatment of necrotizing soft tissue infections. STUDY DESI
GN A ten-year retrospective case series was analyzed. RESULTS: Data fr
om 29 patients were analyzed. Among patients undergoing early operatio
n within 24 hours of admission (n=17) there was one death (6 percent m
ortality rate); survivors averaged 2.9 operations per patient. By comp
arison, of patients with delayed operation (n=12) three died (25 perce
nt mortality rate) and there were 3.6 operations per patient. Positive
fine-needle aspiration (FNA) of suspicious lesions, demonstrating eit
her pus or bacteria by Gram's stain, led to early operation in 80 perc
ent of patients tested. Patients with soft tissue gas on radiographs w
ere more likely to undergo early operation (58 percent). Delayed opera
tion was more common in the absence of radiographic findings. All pati
ents admitted to nonsurgical services had delayed operations. CONCLUSI
ONS: Suspected necrotizing soft tissue infections require prompt surgi
cal evaluation and early operative exploration. Early operation with d
efinitive surgical therapy initiated within 24 hours of admission is a
ssociated with decreased mortality rates. Negative FNA findings, nondi
agnostic radiographs, and admission to a nonsurgical service correlate
with delay in definitive operative intervention.