BIOLOGICAL-ACTIVITY OF DISULFATED POLYHYDROXYSTEROIDS FROM THE PACIFIC BRITTLE STAR OPHIOPHOLIS-ACULEATA

Authors
AMININ DL AGAFONOVA IG FEDOROV SN
Citation
Dl. Aminin et al., BIOLOGICAL-ACTIVITY OF DISULFATED POLYHYDROXYSTEROIDS FROM THE PACIFIC BRITTLE STAR OPHIOPHOLIS-ACULEATA, Comparative biochemistry and physiology. Part C, Pharmacology toxicology & endocrinology, 112(2), 1995, pp. 201-204
Citations number
12
Categorie Soggetti
Biology,"Pharmacology & Pharmacy",Toxicology
Journal title
Comparative biochemistry and physiology. Part C, Pharmacology toxicology & endocrinology → ACNP
ISSN journal
13678280
Volume
112
Issue
2
Year of publication
1995
Pages
201 - 204
Database
ISI
SICI code
1367-8280(1995)112:2<201:BODPFT>2.0.ZU;2-L
Abstract
The action of (20R)-cholesta-5,25-diene-3 alpha,4 beta,21-triol 3,21-d isulfate and its 25,26-dihydro-analog from the Pacific brittle star Op hiopholis aculeata was studied on mouse cancer cells, lymphocytes and erythrocytes. The cytotoxic and hemolytic effects were not observed fo r both steroids at the wide range of concentrations. Both steroids inh ibited H-3-Thymidine (but not H-3-Uridine) incorporation into Ehrlich carcinoma cells. It was the first time shown that some sulfated marine polyhydroxylated steroids stimulate the influx of Ca2+ into cells. (2 0R)-Cholesta-5,25-diene-3 alpha,4 beta,21-triol 3,21-disulfate was two times more active than its 25,26-dihydro-analog.