Ag. Turkcapar et al., THE EFFECT OF OCTREOTID ON BACTERIAL TRANSLOCATION FROM THE GUT - AN EXPERIMENTAL-STUDY, International surgery, 80(3), 1995, pp. 264-266
Octreotid (OC) is a somatostatin (ST) analog which is being increasing
ly used during the management of various gastrointestinal disorders, T
his study was undertaken to assess the probable effects of OC on intra
intestinal microflora and bacterial translocation, To our knowledge, n
o previous work has addressed this issue, Ten rats forming the study g
roup were injected 20 mu g/kg of OC subcutaneously for seven days, A c
ontrol group (n=10) received an equal volume of isotonic saline for se
ven days, All animals were sacrificed on the eighth day and tissue cul
tures were obtained from the mesenteric lymph nodes, liver, and spleen
, Cultures were also made from the caecal content and a piece of termi
nal ileum was removed for histopathological examination, For statistic
al analysis, Mann Whitney-U, and Fisher's exact tests were used, Caeca
l bacterial content, and bacterial translocation were found to be sign
ificantly increased in the study group in comparison to the control gr
oup (p<0.05). Among the study group, there was also a statistically si
gnificant increase in the caecal bacterial content in rats with eviden
ce of bacterial translocation (p<0.05). Histopathological evaluation d
rew a great deal of attention to submucosal edema present in the study
group, OC significantly increases bacterial overgrowth, and transloca
tion in rats, Studies on humans are needed to demonstrate similar clin
ical effects of OC.