OVERVIEW - PRACTICAL INSIGHTS FROM COMPARATIVE IMMUNOLOGY AND PATHOGENESIS OF AIDS, HEPATITIS-B, AND MEASLES FOR DEVELOPING AN HIV VACCINE

Combined effects of viral mutation, beneficial and adverse host immune responses, and alterations in immune function strongly fashion the pa thogenesis and outcome of HIV infection. Understanding HIV can be aide d by understanding hepatitis B and measles. Clinical remission and exa cerbation in persistent hepatitis B virus infection is determined by t he triad of viral mutation, induction of anergy, and host immune respo nses. Measles virus infects many of the same kinds of cells as HIV and causes an immunodeficiency as well that usually is spontaneously reve rsible. Lessons learned from comparative studies can assist in plottin g approaches and strategies for immunoprophylactic and therapeutic int erventions in HIV infections and AIDS.