3-COMPONENT MODEL OF ESTROGEN FORMATION AND REGULATION OF INTRATUMORAL ESTROGEN POOL IN BREAST NEOPLASMS

Authors
BERSTEIN LM SANTEN RJ SANTNER SJ
Citation
Lm. Berstein et al., 3-COMPONENT MODEL OF ESTROGEN FORMATION AND REGULATION OF INTRATUMORAL ESTROGEN POOL IN BREAST NEOPLASMS, Medical hypotheses, 45(6), 1995, pp. 588-590
Citations number
23
Categorie Soggetti
Medicine, Research & Experimental
Journal title
Medical hypotheses → ACNP
ISSN journal
03069877
Volume
45
Issue
6
Year of publication
1995
Pages
588 - 590
Database
ISI
SICI code
0306-9877(1995)45:6<588:3MOEFA>2.0.ZU;2-G
Abstract
Although a two-component model system (i.e. epithelial and stromal spi ndle-shaped cells) may explain the regulation of aromatase activity an d the location of possible intratumoural sources of oestrogen producti on in mammary neoplasms, a third component, consisting of lymphocytes and macrophages, may also be considered. Examples are presented, sugge sting the importance of a three-component model for a more complete un derstanding of the regulation of oestrogen production in breast-tumour tissue.