THE HISTOPATHOLOGY OF THE IRIDOCORNEAL-ENDOTHELIAL SYNDROME

The iridocorneal-endothelial (ICE) syndrome is characterised clinicall y by a ''hammered-silver'' appearance of the corneal endothelium, corn eal failure, glaucoma, and iris destruction. Specular photomicroscopic studies of the corneal endothelium have demonstrated a population of abnormal cells termed ''ICE cells.'' The purpose of this study was to define the histological appearances typical of this disease and in par ticular the ultrastructural morphology of the ICE cell, Thirty-five co rneas, 11 trabeculectomy specimens, and 3 failed corneal grafts taken from patients with the ICE syndrome were examined by transmission and scanning electron microscopy. Comparison was made with seven normal co rneas. Ten corneas and two trabeculectomy specimens demonstrated a pop ulation of well-differentiated cells with epithelial features such as desmosomes, tonofilaments, and microvilli. Other cell types identified were cells that resembled those of normal corneal endothelium, inflam matory cells, and cells with a fibroblast-like morphology. It seems li kely that the epithelial cells of our specimens are the histological e quivalent of the ICE cell seen by specular photomicroscopy. The other cell types may be either residual normal endothelial cells or else ari se from secondary phe nenomena of various kinds.