STRESS AND RADIORESISTANCE (GENETIC-ASPECTS)

Inbred mice and randomly bred stock were exposed to long-term adrenali ne and hypothermia stress effects for unification of their functional status, followed by acute total gamma irradiation by equal-effect dose s (LD(50/30)). The significant reduction of lethality distribution in inbred mice after combined stress and radiation effects was observed. The spread of lethality in random bred stock was increased as compared to the control group. The post-irradiation mortality in experimental animals differed only slightly from the values in the control groups. Conclusions are drawn about the principal meaning of genotype in radio sensitivity, about the role of an organism's functional status in dete rmination of death date and about the possible epigenetic structuralis ation of linear mice by radioresistance.