6-YEAR OBSERVATION OF IMMUNE STATE OF PERSONS AFFECTED BY THE CHERNOBYL ACCIDENT

The results of immunological monitoring, immuno-epidemiological invest igations and analysis of medical documentation carried out in two Brya nsk Region territories situated in the isoline of radioactive contamin ation (55.5 x 10(10) to 148 x 10(10) Bq.km(-2)) with tested population s of 3892 and 1074 persons respectively, are presented. An immunodefic iency risk group and the distribution of various chronic diseases in t he tested territories were discovered to be considerably larger than i n the regions of comparison and in cities of the Russian and Ukrainian non-background zone. The immune state of 'dirty' Vyshkov settlement i nhabitants as compared to one of the 'clean' Pochep population was cha racterised by CD4+ and CD5+ activation, increase of CD4+/CD8+ value an d phagocytosis rate in the presence of serum IgG and IgM deficit. Novo zybkov city inhabitants were found to have increased T supressor/kille r rate. The highest CD4+, CD5+, CD4+/CD8+ rate values were found to oc cur against the background of clinical symptoms which could be attribu ted to radiation impact: loss of hair and teeth, surplus weight, predi sposition to bleeding, especially noticed among cattle breeders.