MUTAGENIC POTENTIAL OF ACUTE EXPOSURE TO ORGANOPHOSPHORUS AND ORGANOCHLORINE COMPOUNDS

Authors
VIJAYARAGHAVAN M NAGARAJAN B
Citation
M. Vijayaraghavan et B. Nagarajan, MUTAGENIC POTENTIAL OF ACUTE EXPOSURE TO ORGANOPHOSPHORUS AND ORGANOCHLORINE COMPOUNDS, MUTATION RESEARCH, 321(1-2), 1994, pp. 103-111
Citations number
20
Categorie Soggetti
Genetics & Heredity",Toxicology
Journal title
MUTATION RESEARCH → ACNP
ISSN journal
00275107
Volume
321
Issue
1-2
Year of publication
1994
Pages
103 - 111
Database
ISI
SICI code
0027-5107(1994)321:1-2<103:MPOAET>2.0.ZU;2-C
Abstract
The cytogenetic and cytotoxic effects of the pesticides methyl parathi on, Bayleton and Hinosan were evaluated in mammalian test systems. The frequency of chromosome aberrations and micronuclei in bone marrow ce lls and the arginase enzyme profile in the liver tend to show the geno toxicity of organophosphorus and organochlorine pesticides in a single -exposure response study. Methyl parathion was the most hazardous amon g the three, showing definite pathology in the livers of treated rats.