STRUCTURE-ACTIVITY RELATIONSHIP OBSERVATIONS FOR EUROPEAN CORN-BORER MOTH PHEROMONE AND FLUORO ANALOGS VIA COMPUTER MOLECULAR MODELING

Structure-activity relationship (SAR) observations were made for the Z -type European corn borer moth pheromone, (Z)-11-tetradecen-1-ol aceta te, and a series of analogs with fluorination in the alcohol portion o f the molecule. The attractiveness of these analogs and the pheromone was compared to the electrostatic potential map of the molecular mecha nics (MM) minimized lowest energy conformation for each compound. A cr itical range of electrostatic potential on the protons of the double-b ond appears to be essential for optimal acceptor fit and attractivenes s.