A 63-year-old woman developed a clinical and pathological picture of p
olyarteritis nodosa (PAN). Systemic lupus erythematosus (SLE) had been
diagnosed 12 years previously, and she had been symptom and therapy-f
ree for a decade. Development of 'primary' systemic vasculitis in SLE
patients has rarely been described previously and the significance of
this association remains unclear. The possible explanation for this tr
ansition from one connective tissue disease to another is discussed.