INTRANASAL LYSINE ASPIRIN IN RECURRENT NASAL POLYPOSIS

Twenty patients with recurrent nasal polyposis but without any history of aspirin sensitivity were given 2000 mu g of intranasal lysine aspi rin to one nostril and saline to the other once a week for periods of up to 15 months. Two patients had increased nasal obstruction followin g the initial test doses of lysine aspirin and were excluded from the the trial proper. In the remainder symptomatic polyp recurrence was de layed compared with the previous experience while on intranasal steroi ds, with eight patients remaining symptom free at 15 months compared w ith an expected number of three (P = <0.05, chi(2) test). Polyp recurr ence was bilateral but there was a tendency for the lysine aspirin tre ated side to have less polyp tissue as assessed by nasendoscopy and by acoustic rhinometry.