CARBOPLATIN TREATMENT INDUCES DOSE-DEPENDENT INCREASES IN THE FREQUENCY OF MICRONUCLEI IN EHRLICH ASCITES TUMOR-CELLS

Authors
QUINTANA E PERTUSA J GONZALEZ R RENAUPIQUERAS J
Citation
E. Quintana et al., CARBOPLATIN TREATMENT INDUCES DOSE-DEPENDENT INCREASES IN THE FREQUENCY OF MICRONUCLEI IN EHRLICH ASCITES TUMOR-CELLS, MUTATION RESEARCH, 322(1), 1994, pp. 55-60
Citations number
40
Categorie Soggetti
Genetics & Heredity",Toxicology
Journal title
MUTATION RESEARCH → ACNP
ISSN journal
00275107
Volume
322
Issue
1
Year of publication
1994
Pages
55 - 60
Database
ISI
SICI code
0027-5107(1994)322:1<55:CTIDII>2.0.ZU;2-#
Abstract
The effect of various doses (75-300 mg/kg b.w.) of carboplatin on the induction of micronuclei in Ehrlich ascites tumor (EAT) cells was stud ied. Carboplatin treatment resulted in a dose-dependent increase in th e frequency of micronucleated EAT cells. Carboplatin treatment also de creased the mitotic index. The dose-effect curves were linear-quadrati c for all the parameters studied. The maximal effect of the drug was o btained in all the treatments after 48 h.