IN-VIVO DISTRIBUTION OF FERRIC-ATP COMPLEX

At physiological pH, ferric-ATP complex presents ionic characteristics unlike those of ferric lactate. Its rapid diffusion into the tissues, and its reactivity which is not impaired by polymerization seem respo nsible for its toxicity. In comparison with ferric lactate, after pare nteral administration there is a much higher spleen, lung, kidney and bone accumulation. After oral administration, on the other hand, the v alues are lower. ATP hydrolysis by the stomach's pH, and the subsequen t iron insolubilisation as phosphate could be the reason for this beha viour.