Sc. Sahu et Cj. Dominic, CHLORPROMAZINE PREVENTS THE NUTRITIONAL STRESS-INDUCED IMPLANTATION FAILURE IN MICE, National Academy Science Letters, 18(7-8), 1995, pp. 149-151
Implantaiton failure in newly inseminated mice induced by food depriva
tion for 48 h beginning at 10.00 hr on day 2 or day 4 post coitum was
prevented by administration of chlorpromazine (CPZ), 150 mu g/female/d
ay, for 5 days coincident with the beginning of inanition; most famale
s carried pregnancy to term and delivered viable young. It is suggeste
d that the CPZ- induced release of hypophyseal prolactin sustained the
corpora lutea during nutritional stress and protected implantation in
females. The results support the view that depression of hypophyseal
prolactin release is the key endocrine factor that causes implantation
failure in food-deprived females.