ENGINEERING MACROMOLECULAR SELF-ASSEMBLY - MOLECULAR TUBES VS PROTEINSHEETS VIA SINGLE AMINO-ACID SUBSTITUTIONS IN ESCHERICHIA-COLI GLUTAMINE-SYNTHETASE

Communication: Protein engineering provides a rationale for obtaining self-assembling molecules which yield supramolecular arrays with varyi ng quaternary architectures. An example is E. coli glutamine synthetas e which can be manipulated to yield molecular tubes (see figure), cabl es, and hexagonally packed sheets.