A PERSONAL VIEW OF SOME CONTROVERSIES IN ALLOCATING TREATMENT TO PATIENTS IN CLINICAL-TRIALS

Authors
SENN S
Citation
S. Senn, A PERSONAL VIEW OF SOME CONTROVERSIES IN ALLOCATING TREATMENT TO PATIENTS IN CLINICAL-TRIALS, Statistics in medicine, 14(24), 1995, pp. 2661-2674
Citations number
41
Categorie Soggetti
Statistic & Probability","Medicine, Research & Experimental","Public, Environmental & Occupation Heath","Statistic & Probability","Medical Informatics
Journal title
Statistics in medicine → ACNP
ISSN journal
02776715
Volume
14
Issue
24
Year of publication
1995
Pages
2661 - 2674
Database
ISI
SICI code
0277-6715(1995)14:24<2661:APVOSC>2.0.ZU;2-A
Abstract
A non-exhaustive but nevertheless wide-ranging if biased and personal view of various matters affecting the allocation of treatments to pati ents in controlled clinical trials will be undertaken from the standpo int of a statistician working in drug development. The following topic s are considered: the use of 'placebos' in the run-in phase; the use o f crossover trials; selection of patients; various matters concerning centres; two extreme alternatives to randomization, and various matter s linking blinding and allocation.