EFFECT OF POLYMORPHISM IN THE DROSOPHILA REGULATORY GENE ULTRABITHORAX ON HOMEOTIC STABILITY

Citation
G. Gibson et Ds. Hogness, EFFECT OF POLYMORPHISM IN THE DROSOPHILA REGULATORY GENE ULTRABITHORAX ON HOMEOTIC STABILITY, Science, 271(5246), 1996, pp. 200-203
Citations number
28
Categorie Soggetti
Multidisciplinary Sciences
Journal title
ISSN journal
00368075
Volume
271
Issue
5246
Year of publication
1996
Pages
200 - 203
Database
ISI
SICI code
0036-8075(1996)271:5246<200:EOPITD>2.0.ZU;2-L
Abstract
Development is buffered against unpredictable environmental and geneti c effects. Here, a molecular genetic analysis of one type of developme ntal homeostasis, the establishment of thoracic segmental identity und er the control of the Ultrabithorax (Ubx) gene in Drosophila melanogas ter, is presented. Flies were artificially selected for differential s ensitivity to the induction of bithorax phenocopies by ether vapor, Th e experiments demonstrated that increased sensitivity to ether correla ted with a loss of expression of UBX in the third thoracic imaginal di scs and that a significant proportion of the genetic variation for tra nscriptional stability can be attributed to polymorphism in the Ubx ge ne.