FUNCTIONAL-SIGNIFICANCE OF ALTERATIONS IN CARDIAC CONTRACTILE PROTEINISOFORMS

Authors
KITSIS RN SCHEUER J
Citation
Rn. Kitsis et J. Scheuer, FUNCTIONAL-SIGNIFICANCE OF ALTERATIONS IN CARDIAC CONTRACTILE PROTEINISOFORMS, Clinical cardiology, 19(1), 1996, pp. 9-18
Citations number
115
Categorie Soggetti
Cardiac & Cardiovascular System
Journal title
Clinical cardiology → ACNP
ISSN journal
01609289
Volume
19
Issue
1
Year of publication
1996
Pages
9 - 18
Database
ISI
SICI code
0160-9289(1996)19:1<9:FOAICC>2.0.ZU;2-E
Abstract
Multiple closely related, yet distinct, isoforms ex ist for each of th e cardiac contractile proteins. The isoform composition of the heart c hanges in response to developmental and physiologic cues. This paper r eviews the molecular basis for cardiac contractile protein isoform div ersity and the functional consequences of isoform shifts.