SYNTHESIS OF 8-OXO-7,8-DIHYDRO-6-O-METHYL-2'-DEOXYGUANOSINE AND ITS USE AS A PROBE TO STUDY DNA-BASE EXCISION BY MUTY ENZYME

Authors
VARAPRASAD CV BULYCHEV N GROLLMAN AP JOHNSON F
Citation
Cv. Varaprasad et al., SYNTHESIS OF 8-OXO-7,8-DIHYDRO-6-O-METHYL-2'-DEOXYGUANOSINE AND ITS USE AS A PROBE TO STUDY DNA-BASE EXCISION BY MUTY ENZYME, Tetrahedron letters, 37(1), 1996, pp. 9-12
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
1
Year of publication
1996
Pages
9 - 12
Database
ISI
SICI code
0040-4039(1996)37:1<9:SO8AIU>2.0.ZU;2-0
Abstract
A 23mer oligomer containing 8-oxo-7,8-dihydro-6-O-methyl-2'-deoxyguano sine (1) has been synthesized from 2'-deoxyguanosine. The activity of MutY protein coward this and a related oligomer containing 8-methoxy-d G has been studied.