ENANTIOSELECTIVE REDUCTION OF KETONES BY BORANE CATALYZED BY OXAZAPHOSPHOLIDINE OXIDES

Authors
CHIODI O FOTIADU F SYLVESTRE M BUONO G
Citation
O. Chiodi et al., ENANTIOSELECTIVE REDUCTION OF KETONES BY BORANE CATALYZED BY OXAZAPHOSPHOLIDINE OXIDES, Tetrahedron letters, 37(1), 1996, pp. 39-42
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
1
Year of publication
1996
Pages
39 - 42
Database
ISI
SICI code
0040-4039(1996)37:1<39:EROKBB>2.0.ZU;2-0
Abstract
New enantioselective catalysts for the asymmetric reduction of ketones by borane are described. Easily prepared by oxidation of chiral oxaza phospholidines, these compounds increase sensitively the reduction rat e of numerous ketones and induce ee's up to 94% in the case of the 2-c hloroacetophenone.