We evaluated the effects of extinction and negative reinforcement on t
he latency of response-class members following requests made to a 15-y
ear-old female with moderate mental retardation and autism. A function
al analysis showed that the class members (screams, aggression, and se
lf-injury) were escape maintained. Informal observations suggested tha
t these topographies generally occurred in the sequence listed above a
nd therefore may have been hierarchically related. A therapist provide
d escape from demands contingent on a specific member of the class to
determine the effects on the latency of the members' occurrence. Resul
ts showed that the latencies occurred in a predictable order. In addit
ion, we expanded the response class to include a vocal response that w
as functionally equivalent to other members. Findings are discussed re
garding the covariation and sequence of response-class members and tre
atment development.