CONTRIBUTION OF SCINTIGRAPHY TO VERIFY THE RELIABILITY OF DIFFERENT PREPARATION PROCESSES FOR ENTERIC-COATED CAPSULES

Authors
CATTEAU D BARTHELEMY C DEVEAUX M ROBERT H TRUBLIN F MARCHANDISE X VANDRUNEN H
Citation
D. Catteau et al., CONTRIBUTION OF SCINTIGRAPHY TO VERIFY THE RELIABILITY OF DIFFERENT PREPARATION PROCESSES FOR ENTERIC-COATED CAPSULES, European journal of drug metabolism and pharmacokinetics, 19(2), 1994, pp. 91-98
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of drug metabolism and pharmacokinetics → ACNP
ISSN journal
03787966
Volume
19
Issue
2
Year of publication
1994
Pages
91 - 98
Database
ISI
SICI code
0378-7966(1994)19:2<91:COSTVT>2.0.ZU;2-W
Abstract
The aim of this work was to use radiopharmaceuticals such as technetiu m (Tc-99m) and indium (DTPA-Ca-In-111) to visualize, with a gamma-came ra, the disintegration area and time of 3 types of enteric coated hard gelatin capsules (obtained by 3 different preparation processes) and thus, to verify that they are really resistant in gastric fluids and s oluble in intestinal zones. Results are well correlated with those pre viously obtained in vitro (disintegration, dissolution) and in vivo (p rofiles of plasmatic concentrations versus time).