LEVODOPA STABILITY IN SOLUTION - TIME-COURSE, ENVIRONMENTAL-EFFECTS, AND PRACTICAL RECOMMENDATIONS FOR CLINICAL USE

Authors
PAPPERT EJ BUHRFIEND C LIPTON JW CARVEY PM STEBBINS GT GOETZ CG
Citation
Ej. Pappert et al., LEVODOPA STABILITY IN SOLUTION - TIME-COURSE, ENVIRONMENTAL-EFFECTS, AND PRACTICAL RECOMMENDATIONS FOR CLINICAL USE, Movement disorders, 11(1), 1996, pp. 24-26
Citations number
10
Categorie Soggetti
Clinical Neurology
Journal title
Movement disorders → ACNP
ISSN journal
08853185
Volume
11
Issue
1
Year of publication
1996
Pages
24 - 26
Database
ISI
SICI code
0885-3185(1996)11:1<24:LSIS-T>2.0.ZU;2-C
Abstract
We defined the temporal stability characteristics of levodopa/carbidop a (LD/CD) solution, and determined the effects of temperature, ascorba te, and light on LD stability over 7 days. At room temperature and wit hout ascorbate, LD levels significantly declined by 48 h. Ascorbate pr olonged stability to 72 h. Refrigeration and freezing prevented a sign ificant decline in LD levels for the full 7 days. Light or darkness ha d no effect on stability. LD/CD solution, if made daily, requires no s pecial handling and longer stability is maintained with ascorbate, ref rigeration, or freezing.