CONDUCTIMETRIC TITRIMETRY FOR ASSAY OF SELECTED ANTIBIOTICS IN NONAQUEOUS MEDIA

In this study, a conductimetric titration method is proposed for the d etermination of some commonly used antibiotics. The conductimetric tit ration of three antibiotics, namely ampicillin, amoxycillin trihydrate and rifampin, was carried out in acetic acid using perchloric acid as titrant. Ciproflaxacin hydrochloride, however, was titrated after bei ng dissolved in acetic acid containing an excess of mercury(II) acetat e. For the titration of netilmicin sulphate, barium acetate prepared i n acetic acid was used as titrant. The method was found to be highly a ccurate and precise, having a relative standard deviation of less than 1.0% for all antibiotics studied. It was also shown that the conducti metric titrimetry could be successfully applied to the assay of commer cial preparations containing the above-mentioned antibiotics. The vali dity of the method was tested by the recovery studies of standard addi tion to pharmaceuticals and the results were found to be satisfactory.