AN HPLC ASSAY FOR THE NORDITERPENOID ALKALOID METHYLLYCACONITINE, A POTENT NICOTINIC ACETYLCHOLINE-RECEPTOR ANTAGONIST

Authors
COATES PA BLAGBROUGH IS LEWIS T POTTER BVL ROWAN MG
Citation
Pa. Coates et al., AN HPLC ASSAY FOR THE NORDITERPENOID ALKALOID METHYLLYCACONITINE, A POTENT NICOTINIC ACETYLCHOLINE-RECEPTOR ANTAGONIST, Journal of pharmaceutical and biomedical analysis, 13(12), 1995, pp. 1541-1544
Citations number
17
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of pharmaceutical and biomedical analysis → ACNP
ISSN journal
07317085
Volume
13
Issue
12
Year of publication
1995
Pages
1541 - 1544
Database
ISI
SICI code
0731-7085(1995)13:12<1541:AHAFTN>2.0.ZU;2-J
Abstract
The extremely potent and selective nicotinic acetylcholine receptor an tagonist methyllycaconitine, MLA, and related norditerpene alkaloids a re finding increasing use as neurochemical probes and as targets for s tructure-activity relationship studies. In this work, an assay procedu re for MLA which utilises ion suppression reverse-phase HPLC with UV a bsorbance detection at 270 nm is described. The method detected 280 ng MLA on column.