EFFECT OF TRIIODOTHYRONINE ADMINISTRATION IN EXPERIMENTAL MYOCARDIAL INJURY

Twelve healthy pigs were subjected to a 20-min, period of regional myo cardial ischemia by snaring the left anterior descending coronary arte ry (LAD) between its first and second diagonal branches. The resulting myocardial injury caused significant acute hemodynamic impairments. C ardiac index declined significantly during reperfusion interval and re turned to preischemic level by postoperative day 7. Plasma total triio dothyronine (TT3), free triiodothyronine (FT3) and free fatty acid (FF A) decreased gradually and reached the nadir at 6 h after LAD occlusio n. In contrast, plasma reverse triiodothyronine (rT(3)) increased prog ressively after LAD occlusion and reperfusion. To investigate the effe ct of T-3 on ischemic myocardium, T-3 (0.2 mu g/kg/dose; n=5) or salin e (placebo; n=6) was administered immediately, 30 min, 60 min, 90 min, and 120 min after reperfusion, Plasma TT3 and FT3 increased dramatica lly after triiodothyronine supplement but declined to presichemic leve l at six h after LAD occlusion, The pigs treated with T-3 demonstrated a rapid improvement in cardiac index over the reperfusion interval, w hereas cardiac index in the placebo group remained depressed. Myocardi al oxygen consumption estimated by rate pressure product showed no dif ference between placebo and T-3-treated groups. Oxygen extraction as O -2 saturation difference between aorta and coronary sinus was less in T-3-treated group. Nine pigs (four in the T-3-treated group and five i n the placebo group) were subjected to euthanasia with hypertonic KCl solution on postoperative day 7. Myocardial infarct size determined by triphenyltetrazolium chloride (TTC) tissue enzyme staining technique was not significantly different between T-3-treated and placebo groups . We concluded that this animal model is a useful model of myocardial injury simulating ''euthyroid sick syndrome'' as seen in patients with cardiopulmonary bypass, and T-3 supplementation after reperfusion sig nificantly enhanced postischemic left ventricular functional recovery but did not affect myocardial oxygen consumption and myocardial infarc t size.